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Published on: March 3, 2013
Mechanical buckling of arterioles in collateral development
1Department of Mechanical Engineering, University of Texas at San Antonio, TX 78249, USA.
Journal of Theoretical Biology
|October 5, 2012
Summary
Arteriole remodeling, specifically axial growth, increases the likelihood of buckling, leading to the corkscrew patterns seen in collateral vessels. This buckling is a key factor in collateral arteriole tortuosity.
Area of Science:
- Biomedical Engineering
- Cardiovascular Physiology
- Vascular Biology
Background:
- Collateral arterioles exhibit increased diameter, length, and tortuosity during remodeling.
- Artery buckling has been recently identified as a potential cause of vascular tortuosity.
Purpose of the Study:
- To determine the critical buckling pressure of arterioles.
- To investigate the buckling patterns in remodeling arterioles.
Main Methods:
- Modeled arterioles as elastic cylindrical vessels with elastic matrix support.
- Simulated axial and radial growth in the arteriole models.
Main Results:
- Critical buckling pressure decreased with greater axial and radius growth ratios but increased with wall thickness.
- Buckling mode number increased with axial growth ratio, while decreasing with radius growth ratio and wall thickness.
Conclusions:
- Axial growth in arterioles significantly increases their susceptibility to buckling.
- Buckling is a primary mechanism driving the development of tortuosity in collateral arterioles.
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