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Updated: May 18, 2026

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
Mixed-strain mycobacterium tuberculosis infections and the implications for tuberculosis treatment and control
Ted Cohen1, Paul D van Helden, Douglas Wilson
1Division of Global Health Equity, Brigham and Women's Hospital, Boston, Massachusetts, USA. tcohen@hsph.harvard.edu
Abstract:
Numerous studies have reported that individuals can simultaneously harbor multiple distinct strains of Mycobacterium tuberculosis. To date, there has been limited discussion of the consequences for the individual or the epidemiological importance of mixed infections. Here, we review studies that documented mixed infections, highlight challenges associated with the detection of mixed infections, and discuss possible implications of mixed infections for the diagnosis and treatment of patients and for the community impact of tuberculosis control strategies. We conclude by highlighting questions that should be resolved in order to improve our understanding of the importance of mixed-strain M. tuberculosis infections.
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