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Poly(2-oxazoline)s--are they more advantageous for biomedical applications than other polymers?
Ondrej Sedlacek1, Bryn D Monnery, Sergey K Filippov
1Institute of Macromolecular Chemistry, vvi, Academy of Sciences of the Czech Republic, Prague 6, Czech Republic.
Abstract:
Poly(2-alkyl-2-oxazoline)s are biocompatible polymers with polypeptide-isomeric structures that are attracting increasing interest as biomaterials for drug, gene, protein, and radionuclide delivery. They are, however, still relatively new in comparison to other classes of hydrophilic water-soluble polymers already established for such use, including poly(ethylene oxide), polyvinylpyrrolidone, and polymethacrylamides such as poly[N-(2-hydroxypropyl)methacrylamide]. This feature article critically compares the synthetic aspects and physicochemical and biological properties of poly(2-alkyl-2-oxazoline)s and these commonly studied polymers in terms of their suitability for biomedical applications.
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