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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Esophageal Achalasia01:27

Esophageal Achalasia

Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide (VIP)...
Types of Intermediate Filaments01:31

Types of Intermediate Filaments

The intermediate filaments are an essential component of the cytoskeleton. Presently six types of intermediate filament have been identified. Type I and II are acidic and basic keratin proteins. Type III is of mesodermal origin and comprises four proteins: vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Vimentin is commonly found in mesenchymal cells, desmin in muscle cells, GFAP in astrocytes, while peripherin is found in peripheral nervous system neurons (PNS). Type...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

Ultrasound II: Endoscopic Ultrasound and FibroScan

Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):

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Related Experiment Video

Updated: May 18, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
03:23

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Published on: May 10, 2024

Eosinophilic fasciitis.

Ka Lai Tsoi1, Martijn Custers, Liesbeth Bij de Vaate

  • 1Rheumatology Department, University Medical Center Utrecht, Utrecht, Netherlands. kalaitsoi@hotmail.com

BMJ Case Reports
|October 5, 2012
PubMed
Summary

This case study highlights a 57-year-old woman diagnosed with eosinophilic fasciitis, a rare inflammatory condition. Early symptoms included limb heaviness and swelling, confirmed by biopsy and blood tests revealing eosinophilia.

Area of Science:

  • Rheumatology
  • Dermatology
  • Internal Medicine

Background:

  • Eosinophilic fasciitis is a rare inflammatory disorder affecting connective tissues.
  • It can present with non-specific symptoms like malaise and limb heaviness, mimicking other conditions.

Observation:

  • A 57-year-old woman experienced progressive edema and skin induration in her extremities.
  • Initial presentation lacked clear signs of inflammation, complicating early diagnosis.

Findings:

  • Blood tests revealed significant eosinophilia.
  • Generalized lymphadenopathy was noted.
  • A full-thickness skin biopsy confirmed the diagnosis of eosinophilic fasciitis after excluding infectious and malignant etiologies.

Implications:

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Published on: May 10, 2024

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  • This case underscores the importance of considering eosinophilic fasciitis in patients with unexplained edema and eosinophilia.
  • Diagnostic confirmation via skin biopsy is crucial for appropriate management.
  • Early recognition and diagnosis are key to preventing long-term complications associated with eosinophilic fasciitis.