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Decrease in perfusion of cerebral capillaries during incomplete ischemia and reperfusion.

S R Ennis1, R F Keep, G P Schielke

  • 1Department of Pediatrics, University of Michigan, Ann Arbor 48109-0532.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|March 1, 1990
PubMed
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Unilateral cerebral ischemia significantly reduced cerebral blood flow (CBF) and capillary perfusion. Early reperfusion showed a mismatch between CBF and perfusion, with selective sodium transport stimulation.

Area of Science:

  • Neuroscience
  • Cerebrovascular Physiology
  • Ischemia-Reperfusion Injury

Background:

  • Cerebral ischemia can lead to significant disruptions in brain function.
  • Understanding the impact on cerebral blood flow (CBF) and microcirculation is crucial.

Purpose of the Study:

  • To investigate the effects of unilateral, incomplete cerebral ischemia on CBF, solute flux, and capillary perfusion.
  • To analyze changes during both ischemia and reperfusion phases.

Main Methods:

  • Gerbil model of unilateral carotid occlusion to induce cerebral ischemia.
  • Measurement of CBF, unidirectional flux of alpha-aminoisobutyric acid (AIB) and sodium.
  • Quantification of perfused capillaries in the cerebral cortex.

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Main Results:

  • Three hours of ischemia reduced ipsilateral CBF by 81% and capillary perfusion by 54%.
  • Reperfusion restored CBF but showed a persistent deficit in capillary perfusion and reduced AIB flux.
  • Sodium transfer constants returned to baseline, suggesting selective ion transport stimulation.

Conclusions:

  • Unilateral carotid occlusion impairs capillary perfusion during ischemia.
  • Early reperfusion exhibits a mismatch between CBF and capillary perfusion.
  • Sodium transport may be selectively stimulated in the early post-ischemic period.