[Effect of the selective ligands 5-HT(1A) receptors administration on the impulsive and self-control behavior in...

The influence of drugs, agonist and antagonist of serotonin receptors 5-HT(1A) on the behavior of rats tested by the method of choice to the value of reinforcement was investigated. Depending on their preferences in food reinforcement rats were divided into self-monitoring (choosing more valuable, delayed reinforcement) and impulsive (low value, immediate reinforcement). An hour before the test animals were administrated i.p. agonist 5-HT(1A) receptors 8-OH-DPAT, [(+)-8-Hydroxy-2-(dipropylamino)tetralin] in a dose of 0.1 mg/kg or antagonist WAY-100635, [N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide maleat salt] at a dose of 0.2 mg/kg. Evaluated parameters, such as number of clicks on a particular pedal, the latencies and number of omitted responses. The results showed that the administration of drugs to modify individual behavior parameters both groups of animals. The introduction of 5-HT(1A) agonist receptors in impulsive animals caused an increase in the number of clicks on the pedal for more valuable reinforcement, and administration of an antagonist did not have any significant effect to behavior.