Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Prolonged Use of Postoperative Gabapentin After Discharge From a Skilled Nursing Facility.

Journal of the American Geriatrics Society·2026
Same author

Tamsulosin Deprescribing for Lower Urinary Tract Symptoms in Older Men: A Randomized Clinical Trial.

JAMA network open·2026
Same author

Identification of Potentially Inappropriate Medications for Adults Below 65 Years: Protocol for a Modified Delphi Study.

JMIR research protocols·2026
Same author

Deprescribing Inappropriate Medicines Across a Health System-Can We Improve the Care of Both Patients and Physicians?

JAMA internal medicine·2026
Same author

Deprescribing and its non-inferiority complex.

The lancet. Healthy longevity·2026
Same author

Medication Management Among Older Adults Living Alone With Cognitive Impairment.

JAMA internal medicine·2026

Related Experiment Video

Updated: May 18, 2026

Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

Patterns of multimorbidity in elderly veterans.

Michael A Steinman1, Sei J Lee, W John Boscardin

  • 1Division of Geriatrics, University of California at San Francisco, San Francisco, California, USA. Mike.steinman@ucsf.edu

Journal of the American Geriatrics Society
|October 6, 2012
PubMed
Summary

Older adults commonly have multiple chronic conditions. Disease patterns vary by age, with hypertension and hyperlipidemia frequently co-occurring, especially in men.

Related Experiment Videos

Last Updated: May 18, 2026

Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

Area of Science:

  • Gerontology
  • Chronic Disease Epidemiology
  • Health Services Research

Background:

  • Older adults frequently experience multiple chronic conditions (MCCs), complicating healthcare.
  • Understanding co-occurring disease patterns is crucial for effective clinical management and public health.
  • Existing research often aggregates older adults, potentially masking age-specific variations in disease combinations.

Purpose of the Study:

  • To identify prevalent patterns of co-occurring diseases in older adults.
  • To examine how these disease patterns differ between the 'young-old' (65-74 years) and the 'old-old' (85+ years) populations.
  • To inform the development of clinical guidelines that address the complexity of MCCs in aging populations.

Main Methods:

  • An observational study utilizing data from the Department of Veterans Affairs (VA) and Medicare.
  • Analysis included 1.9 million men and 39,000 women aged 65 and older with at least two healthcare visits.
  • The presence of 23 common conditions was determined using hospital discharge and outpatient encounter diagnoses.

Main Results:

  • The average number of chronic conditions per individual was 5.5 for men and 5.1 for women.
  • Hypertension, hyperlipidemia, and coronary heart disease were the most common co-occurring conditions in men (37%).
  • Hypertension, hyperlipidemia, and arthritis were most common in women (25%), with significant variations observed between younger and older age groups.

Conclusions:

  • Specific combinations of chronic diseases are highly prevalent in older adults.
  • These co-occurrence patterns differ between younger and older segments of the elderly population.
  • Findings support the need for guidelines addressing the simultaneous management of multiple chronic conditions.