Related Experiment Videos
Widespread cutaneous necrosis associated with cardiolipin antibodies
A O'Neill1, P A Gatenby, B McGaw
1Royal Prince Alfred Hospital, Sydney, N.S.W., Australia.
Insights
Antiphospholipid antibodies are linked to various conditions. This case highlights a patient with anticardiolipin antibodies experiencing skin necrosis and blood vessel thrombosis, illustrating a specific clinical correlation.
Area of Science:
- Immunology
- Pathology
- Dermatology
Background:
- Antiphospholipid antibodies are associated with diverse clinical manifestations.
- The precise correlation between specific antibody assays and clinical conditions remains unclear.
- Various techniques exist for measuring antiphospholipid antibodies, adding complexity to interpretation.
Abstract:
Many clinical phenomena have been described in association with antiphospholipid antibodies, which are measured by a variety of techniques. The relationship of each assay is not completely clear, nor is it apparent which assay correlates best with the various clinical conditions. We describe a patient with anticardiolipin antibodies but without lupus inhibitor who had widespread cutaneous necrosis and underlying thrombosis in dermal blood vessels.