Related Experiment Video

Updated: May 18, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Predictive factors associated with change rates of LV hypertrophy and renal dysfunction in CKD patients

Kozue Okumura1, Hiroaki Io, Mayumi Matsumoto

  • 1Department of Internal Medicine, Juntendo University, Tokyo, Japan.

Clinical Nephrology
|October 6, 2012
PubMed

Insights

Treating anemia and hypertension in chronic kidney disease (CKD) patients may slow kidney dysfunction and prevent left ventricular hypertrophy (LVH). This study identifies key factors influencing these conditions.

Area of Science:

  • Nephrology
  • Cardiology
  • Biochemistry

Background:

  • Chronic kidney disease (CKD) is associated with significant cardiovascular complications.
  • Left ventricular mass index (LVMI) and estimated glomerular filtration rate (eGFR) are key indicators of CKD progression and cardiovascular risk.
  • Factors influencing the rate of change in eGFR and LVMI in pre-dialysis CKD patients are not fully understood.

Purpose of the Study:

  • To investigate the factors associated with changes in eGFR and LVMI in pre-dialysis CKD patients.
  • To identify independent risk factors for the progression of renal dysfunction and left ventricular hypertrophy.
  • To provide insights for therapeutic strategies to manage CKD and its cardiovascular sequelae.

Main Methods:

  • Longitudinal study design with baseline and follow-up assessments in pre-dialysis CKD patients.
  • Echocardiography for LVMI evaluation and biochemical/physical measurements, including blood and urine samples.
  • Multivariate regression analysis to identify independent risk factors for changes in eGFR and LVMI.

Main Results:

  • Changes in hemoglobin (Hb) and transferrin saturation (TSAT) were independent risk factors for eGFR changes.
  • In the LVMI improvement group, systolic blood pressure (sBP) change rate was a significant factor.
  • In the LVMI worsening group, changes in sBP, proteinuria, and Hb were independent risk factors for LVMI changes.

Conclusions:

  • Treatment of renal anemia and iron deficiency anemia may prevent the progression of renal dysfunction.
  • Managing hypertension, renal anemia, and proteinuria is crucial for preventing left ventricular hypertrophy in CKD patients.
Abstract

Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...