Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 18, 2026

A Mouse Distraction Osteogenesis Model
04:24

A Mouse Distraction Osteogenesis Model

Published on: November 14, 2018

A lattice-based approach to model distraction osteogenesis.

E Reina-Romo1, M J Gómez-Benito, J Domínguez

  • 1Department of Mechanical Engineering, University of Seville, 41092-Seville, Spain. erreina@us.es

Journal of Biomechanics
|October 6, 2012
PubMed
Summary

This study simulates bone distraction using a novel discrete-continuum lattice model, offering a more realistic approach to bone regeneration and blood vessel growth compared to traditional methods.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Non-linear Characterization of Commercial and Decellularized Hydrogels: Statistical Framework Enhanced by Bayesian Optimization.

Cellular and molecular bioengineering·2026
Same author

A 3D parametric model of the endothelial monolayer to predict its barrier integrity: Influence of mechanical and geometric conditions.

Computer methods and programs in biomedicine·2026
Same author

Editorial: Integrating computational modeling and organoid technology for enhanced biological research.

Frontiers in bioengineering and biotechnology·2025
Same author

Mechanotherapy as an alternative for cancer treatment.

Physics of life reviews·2024
Same author

Exploring the potential of Physics-Informed Neural Networks to extract vascularization data from DCE-MRI in the presence of diffusion.

Medical engineering & physics·2024
Same author

A multiscale orchestrated computational framework to reveal emergent phenomena in neuroblastoma.

Computer methods and programs in biomedicine·2023

Area of Science:

  • Orthopedics
  • Biomedical Engineering
  • Computational Biology

Background:

  • Distraction osteogenesis is a surgical technique to regenerate bone tissue.
  • Current computational models use continuum approaches, leaving aspects of bone regeneration not fully understood.
  • Intense research is ongoing to refine distraction osteogenesis simulation and understanding.

Purpose of the Study:

  • To simulate bone distraction using a combined discrete-continuum approach based on a lattice formulation.
  • To compare the lattice-based model with existing continuum models.
  • To enhance the understanding of cellular and tissue interactions during bone regeneration.

Main Methods:

  • A combined discrete-continuum approach utilizing a lattice formulation.

More Related Videos

An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur
09:26

An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur

Published on: October 23, 2017

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
07:35

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects

Published on: April 11, 2012

Related Experiment Videos

Last Updated: May 18, 2026

A Mouse Distraction Osteogenesis Model
04:24

A Mouse Distraction Osteogenesis Model

Published on: November 14, 2018

An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur
09:26

An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur

Published on: October 23, 2017

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
07:35

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects

Published on: April 11, 2012

  • Simulation of cell population and tissue distributions.
  • Inclusion of discrete random walk models for cell migration and proliferation.
  • Explicit simulation of blood vessel growth with endothelial cells.

    • Main Results:

    • The lattice-based model shows similarities to continuum models in global cell evolution but differs in ossification processes.
    • Differences were observed in the size of the soft interzone within the distraction gap.
    • The discrete-continuum model offers a more realistic simulation of cell migration, proliferation, and vascularization.

    Conclusions:

    • The discrete-continuum lattice model provides a more realistic simulation of distraction osteogenesis.
    • This approach allows for explicit modeling of blood vessel growth and improved cell migration/proliferation.
    • Further research is needed to fully understand multiscale phenomena in cell-tissue interactions, but this work is a significant step forward.