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Related Concept Videos

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Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
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Related Experiment Video

Updated: May 5, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
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Problems in defining normal limits for serum IgE.

M Klink1, M G Cline, M Halonen

  • 1Division of Respiratory Sciences, University of Arizona College of Medicine, Tucscon 85724.

The Journal of Allergy and Clinical Immunology
|February 1, 1990
PubMed
Summary
This summary is machine-generated.

Serum immunoglobulin E (IgE) levels vary widely across adults. Establishing a single "normal" upper limit for IgE is clinically questionable due to broad value ranges in allergic and non-allergic individuals.

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Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
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Area of Science:

  • Immunology
  • Allergy Research
  • Clinical Diagnostics

Background:

  • Current clinical practice often assumes a universal upper limit for serum immunoglobulin E (IgE) in adults.
  • This approach may not accurately reflect the diverse distribution of IgE levels within the general population.

Purpose of the Study:

  • To describe the distribution of serum IgE levels in a general adult population.
  • To establish age- and sex-specific reference ranges for serum IgE.
  • To evaluate the clinical utility of a single upper IgE limit for distinguishing allergic conditions.

Main Methods:

  • Analysis of serum IgE levels in 2657 subjects from a general population sample.
  • Determination of IgE percentiles (5th to 95th) in a reference group (1569 subjects) with negative allergy skin tests and no current asthma.
  • Comparison of IgE distributions between the reference group and populations with asthma or positive allergy skin tests.

Main Results:

  • Serum IgE levels exhibit extremely wide distributions in both subjects with and without allergic diseases.
  • Age- and sex-specific IgE percentiles were determined for a healthy reference population.
  • IgE distributions differed significantly between the reference group and individuals with asthma or positive allergy skin tests.

Conclusions:

  • A single upper limit of normal for serum IgE has doubtful clinical value due to the broad spectrum of IgE values.
  • Precise distinction between different patient groups using a single IgE cutoff is not feasible.
  • Age- and sex-specific reference ranges are crucial for interpreting serum IgE levels.