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Related Concept Videos

Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.

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Related Experiment Videos

[Lymphomatoid granulomatosis].

H de Boysson1, L Geffray

  • 1Service de médecine interne, centre hospitalier Robert-Bisson, 4, rue Roger-Aini, 14107 Lisieux, France. hubertdeboysson@yahoo.fr

La Revue De Medecine Interne
|October 6, 2012
PubMed
Summary
This summary is machine-generated.

Lymphomatoid granulomatosis is a rare Epstein-Barr virus (EBV)-associated disorder. Histology, EBV status, and B-cell proportion aid in grading and prognosis, distinguishing it from other conditions.

Related Experiment Videos

Area of Science:

  • Pathology
  • Oncology
  • Virology

Context:

  • Lymphomatoid granulomatosis (LG) is a rare Epstein-Barr virus (EBV)-associated lymphoproliferative disorder.
  • It commonly affects the lungs, skin, and central nervous system, often presenting with a systemic course that complicates diagnosis.
  • Its classification remains debated, ranging from indolent forms to aggressive large B-cell lymphomas.

Purpose:

  • To review the clinical, radiological, histological, and therapeutic characteristics of lymphomatoid granulomatosis.
  • To highlight diagnostic challenges and differential diagnoses, including other hematologic malignancies and granulomatosis with polyangiitis.
  • To discuss the prognostic value of disease grading based on atypical B-lymphocytes and EBV status.

Summary:

  • Histologically, LG features an inflammatory angiocentric infiltrate with atypical CD20+ B-lymphocytes and reactive CD3+ T-lymphocytes, often with necrosis.
  • In situ hybridization typically reveals EBV RNA in atypical B-cells.
  • Disease grading (I-III) depends on the proportion of atypical and EBV-positive B-lymphocytes, influencing prognosis and treatment decisions.

Impact:

  • Accurate diagnosis and classification of LG are crucial for appropriate management, as aggressive forms require chemotherapy.
  • Understanding the histological and virological features aids in differentiating LG from mimickers.
  • This review provides a comprehensive overview for clinicians managing this rare disorder.