Related Experiment Video

Updated: May 18, 2026

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
12:50

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Published on: April 14, 2014

ADvanced IMage Algebra (ADIMA): a novel method for depicting multiple sclerosis lesion heterogeneity, as demonstrated

Marios C Yiannakas1, Daniel J Tozer, Klaus Schmierer

  • 1Department of Neuroinflammation, University College London, Institute of Neurology, London, UK. m.yiannakas@ucl.ac.uk

Multiple Sclerosis (Houndmills, Basingstoke, England)
|October 6, 2012
PubMed
Abstract

Insights

ADvanced IMage Algebra (ADIMA) reveals white matter lesion (WML) heterogeneity in multiple sclerosis (MS) using MRI. This novel method reproducibly classifies WMLs into distinct subgroups based on quantitative magnetic resonance properties.

Area of Science:

  • Neuroimaging
  • Radiology
  • Biomedical Engineering

Background:

  • Correlations between multiple sclerosis (MS) disability and white matter lesion (WML) volumes on T2-weighted (T2w) MRI are modest.
  • This limitation may stem from the inability of T2w scans to reveal pathological heterogeneity within WMLs.

Purpose of the Study:

  • To evaluate ADvanced IMage Algebra (ADIMA), a novel MRI post-processing technique.
  • To determine if ADIMA can identify WML heterogeneity using proton-density weighted (PDw) and T2w images.

Main Methods:

  • Conventional PDw and T2w MRI scans from 10 relapsing-remitting MS patients were analyzed.
  • ADIMA was used to segment WMLs into bright (ADIMA-b) and dark (ADIMA-d) sub-regions.
  • Reproducibility of segmentation for ADIMA-b, ADIMA-d, and T2-WML was assessed.

Main Results:

  • ADIMA-derived volumes showed significant correlation with conventional lesion volumes (p < 0.05).
  • ADIMA-b demonstrated distinct quantitative magnetic resonance properties (higher T1/T2, lower MTR) compared to T2-WML (p < 0.001).
  • ADIMA-d exhibited similar quantitative characteristics to T2-WML, with partial overlap observed between regions.

Conclusions:

  • ADIMA effectively classifies WMLs into two distinct subgroups based on quantitative magnetic resonance properties.
  • These subgroups possess different pathological characteristics, offering insights into WML heterogeneity.
  • The ADIMA method provides reproducible classification of WMLs in MS patients.
Keywords:
ADIMAMRI methodsbrain lesion sub-classificationlesion volumemagnetic resonance imagingrelapsing–remitting multiple sclerosiswhite matter lesions

More Related Videos

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

Basics of Multivariate Analysis in Neuroimaging Data06:35

Basics of Multivariate Analysis in Neuroimaging Data

Published on: July 24, 2010

Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...