Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 18, 2026

Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

pH-responsive size-tunable self-assembled DNA dendrimers.

Tao Zhou1, Ping Chen, Lin Niu

  • 1Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, China.

Angewandte Chemie (International Ed. in English)
|October 6, 2012
PubMed
Summary

Researchers developed a DNA self-assembly method to create pure DNA dendrimers. These structures incorporate molecular motors, enabling size changes up to 30% with pH variations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Constrained Layer Damping Perspective on Floating Floor Systems for Low-Frequency Impact Noise Control.

Polymers·2026
Same author

The association of remnant cholesterol inflammatory index with the risk of major adverse cardiovascular events in patients with angina undergoing percutaneous coronary intervention: a retrospective study.

Frontiers in cardiovascular medicine·2026
Same author

Maxillary sinus-related adverse event reports associated with endosseous dental implants in the FDA MAUDE database: a retrospective text-mining analysis.

BMC oral health·2026
Same author

Synergistic modulation of composite donors and π-spacers in porphyrin sensitizers for enhanced charge transfer and photovoltaic efficiency: a DFT/TD-DFT study.

Physical chemistry chemical physics : PCCP·2026
Same author

Epidemiological characteristics of varicella in Xuzhou from 2015 to 2024: surveillance study.

BMC infectious diseases·2026
Same author

2-guanidine-4-methylquinazoline inhibits platelet activation and thrombosis by targeting the acid-sensing ion channel 3.

European journal of pharmacology·2026

Area of Science:

  • Biotechnology
  • Nanotechnology
  • Molecular Biology

Background:

  • DNA dendrimers are complex branched structures with potential applications in nanotechnology and medicine.
  • Current methods for DNA dendrimer synthesis can be complex and yield low purity.
  • Controlling the dynamic properties of nanostructures is crucial for advanced applications.

Purpose of the Study:

  • To present a novel, swift strategy for preparing DNA dendrimers using solely DNA self-assembly.
  • To achieve high purity and yield of high-generation DNA dendrimers.
  • To incorporate responsive elements into DNA dendrimers for tunable size control.

Main Methods:

  • Utilizing DNA self-assembly principles to construct dendritic DNA architectures.
  • Employing i-motifs as molecular motors within the DNA dendrimer framework.

More Related Videos

Designing a Bio-responsive Robot from DNA Origami
13:32

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

Synthesis, Cellular Delivery and In vivo Application of Dendrimer-based pH Sensors
16:19

Synthesis, Cellular Delivery and In vivo Application of Dendrimer-based pH Sensors

Published on: September 10, 2013

Related Experiment Videos

Last Updated: May 18, 2026

Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

Designing a Bio-responsive Robot from DNA Origami
13:32

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

Synthesis, Cellular Delivery and In vivo Application of Dendrimer-based pH Sensors
16:19

Synthesis, Cellular Delivery and In vivo Application of Dendrimer-based pH Sensors

Published on: September 10, 2013

  • Investigating the structural response of the DNA dendrimers to varying pH conditions.

    • Main Results:

    • A highly efficient and rapid method for synthesizing pure DNA dendrimers was established.
    • High generation DNA dendrimers were produced with excellent yields.
    • The DNA dendrimers demonstrated significant, reversible size changes (up to 30%) in response to pH fluctuations.

    Conclusions:

    • The presented DNA self-assembly strategy offers a streamlined approach to DNA dendrimer synthesis.
    • The incorporation of i-motif molecular motors provides a pH-responsive mechanism for size modulation.
    • These findings open avenues for developing smart DNA-based nanostructures with tunable properties.