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Updated: May 18, 2026

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

Elevated neurobehavioral symptoms are associated with everyday functioning problems in chronic methamphetamine users.

Jordan E Cattie¹, Steven Paul Woods, Jennifer E Iudicello

¹Joint Doctoral Program in Clinical Psychology, San Diego State University, La Jolla, CA, USA.

The Journal of Neuropsychiatry and Clinical Neurosciences

|October 6, 2012

Summary

This summary is machine-generated.

Chronic methamphetamine use is linked to significant neurobehavioral symptoms, particularly disinhibition and executive dysfunction. These symptoms correlate with daily living impairments in dependent individuals.

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Area of Science:

Neuroscience
Psychiatry
Addiction Medicine

Background:

Chronic methamphetamine (MA) use is associated with neural injury and neurocognitive deficits.
Neurobehavioral symptoms like apathy, disinhibition, and executive dysfunction are common in MA users.

Purpose of the Study:

To examine the nature and correlates of self-reported neurobehavioral symptoms in individuals with a history of MA dependence.
To determine if these symptoms are linked to functional impairments.

Main Methods:

Compared 73 individuals with MA dependence (MA+) to 85 demographically matched controls.
Assessed neurobehavioral symptoms using the Frontal Systems Behavioral Scale.
Examined associations with comorbidities and instrumental activities of daily living.

Main Results:

MA+ individuals reported significantly more severe neurobehavioral symptoms, especially disinhibition and executive dysfunction.
Symptoms were independent of comorbidities like ADHD, mood disorders, and hepatitis C.
Symptom severity was uniquely associated with decrements in daily living activities in the MA-dependent group.

Conclusions:

Chronic MA users exhibit elevated neurobehavioral symptoms, particularly affecting disinhibition and executive functions.
These symptoms may increase the risk of functional decline in daily life for individuals with MA dependence.