Tissue specific delivery of estrone-conjugated siRNAs
Eun-Kyoung Bang1, Eun Mi Jeon, Wanil Kim
1Department of Chemistry, BK School of Molecular Science, Pohang University of Science and Technology, Pohang 790-784, Korea.
Molecular Biosystems
|October 6, 2012
Abstract:
An estrone phosphoramidite, synthesized in a single step, was directly incorporated at the 5' ends of small interfering RNAs (siRNAs). The resulting estrone-conjugated siRNAs readily pass through cellular membranes and down-regulate the target protein, and show specific distributions in vivo.
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