Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Scientific Method01:32

The Scientific Method

The scientific method is a detailed, empirical problem-solving process used by biologists and other scientists. This iterative approach involves formulating a question based on observation, developing a testable potential explanation for the observation (called a hypothesis), making and testing predictions based on the hypothesis, and using the findings to create new hypotheses and predictions.
Generally, predictions are tested using carefully-designed experiments. Based on the outcome of these...
The Scientific Method02:40

The Scientific Method

Research is what makes the difference between facts and opinions. Facts are observable realities, and opinions are personal judgments, conclusions, or attitudes that may or may not be accurate. In the scientific community, facts can be established only using evidence collected through empirical research.
The Scientific Method03:50

The Scientific Method

Chemistry is an empirical science. Scientists often pose questions to understand the chemistry in everyday life and seek answers to these questions. To achieve this, scientists follow a definitive series of steps that together make up the Scientific Method. This approach involves making observations, asking questions, building a hypothesis, conducting experiments, analyzing results, and forming a conclusion.
Extrasensory Perception01:23

Extrasensory Perception

Extrasensory perception, or ESP, suggests the ability to perceive events beyond the conventional senses of sight, hearing, and touch. Parapsychologists, who research ESP and related psychic phenomena, categorize ESP into three main types: precognition, telepathy, and clairvoyance.
Precognition involves foreseeing future events, such as predicting an accident before it happens. An example of precognition could be someone dreaming about a specific event, like a car crash, which then occurs...
Hindsight Biases01:12

Hindsight Biases

Hindsight bias leads you to believe that the event you just experienced was predictable, even though it really wasn’t. In other words, you knew all along that things would turn out the way they did. Can you relate this to the phrase "Hindsight is 20/20" now?
Inductive Reasoning00:59

Inductive Reasoning

Inductive reasoning is a form of logical thinking that uses related observations to arrive at a general conclusion. It is uncertain and operates in degrees to which the conclusions are credible. As such, inductive arguments can be weak or strong, rather than valid or invalid, and conclusions can be used to formulate testable, falsifiable hypotheses.
Inductive reasoning is common in descriptive science. A life scientist makes observations and records them. This data can be qualitative or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Implausibility of radical life extension in humans in the twenty-first century.

Nature aging·2024
Same author

Geroscience and Its Promise.

Cold Spring Harbor perspectives in medicine·2024
Same author

Aging Like Struldbruggs, Dorian Gray or Peter Pan.

Nature aging·2023
Same author

Personalized Financial Planning Using Applied Genetics.

Cold Spring Harbor perspectives in medicine·2023
Same author

From Life Span to Health Span: Declaring "Victory" in the Pursuit of Human Longevity.

Cold Spring Harbor perspectives in medicine·2022
Same author

Moving geroscience from the bench to clinical care and health policy.

Journal of the American Geriatrics Society·2021
Same journal

Nature-based Virtual Reality for Depression in Alzheimer's Disease: Protocol of a Pilot Randomized Controlled Trial.

Gerontology·2026
Same journal

A Pilot Study of a Multicomponent Interventions in Acute Geriatric Care: Effects on Functional Outcomes and Mobility.

Gerontology·2026
Same journal

Geriatrics co-management of the vulnerable older surgical patient.

Gerontology·2026
Same journal

Title: Same Day Discharge in Primary Total Joint Arthroplasty in Octogenarians: A Case Series and Narrative Review of Optimization Strategies and Perioperative Outcomes.

Gerontology·2026
Same journal

Emotional Reactivity to Daily Physical Symptoms in Adulthood and Old Age: The Role of Different Facets of Social Support.

Gerontology·2026
Same journal

Sex Differences in the Development of a Multidimensional Fall Risk Index for Older Adults.

Gerontology·2026
See all related articles

Related Experiment Video

Updated: May 18, 2026

Visualizing Visual Adaptation
04:43

Visualizing Visual Adaptation

Published on: April 24, 2017

Science fact versus SENS foreseeable.

S Jay Olshansky1, Bruce A Carnes

  • 1Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, IL 60612, USA. sjayo@uic.edu

Gerontology
|October 6, 2012
PubMed
Summary
This summary is machine-generated.

Extending healthy life is a key goal in aging research. This paper argues that proponents of Strategies for Engineered Negligible Senescence (SENS) need empirical evidence, as their core concept of negligible senescence is difficult to test scientifically.

More Related Videos

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
09:13

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Published on: April 22, 2015

Methods for Presenting Real-world Objects Under Controlled Laboratory Conditions
06:54

Methods for Presenting Real-world Objects Under Controlled Laboratory Conditions

Published on: June 21, 2019

Related Experiment Videos

Last Updated: May 18, 2026

Visualizing Visual Adaptation
04:43

Visualizing Visual Adaptation

Published on: April 24, 2017

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
09:13

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Published on: April 22, 2015

Methods for Presenting Real-world Objects Under Controlled Laboratory Conditions
06:54

Methods for Presenting Real-world Objects Under Controlled Laboratory Conditions

Published on: June 21, 2019

Area of Science:

  • Gerontology and regenerative medicine
  • Biomedical research
  • Aging studies

Background:

  • The primary objective in aging research is to extend human healthspan.
  • Strategies for Engineered Negligible Senescence (SENS) propose repairing aging damage to achieve longevity.
  • A critical evaluation of SENS's scientific basis is needed.

Purpose of the Study:

  • To assess the empirical testability of SENS interventions.
  • To examine the challenges in measuring the success of SENS.
  • To highlight the need for scientific rigor in aging research.

Main Methods:

  • Conceptual analysis of SENS principles.
  • Review of scientific methodology in aging research.
  • Discussion of outcome variables for SENS interventions.

Main Results:

  • The central outcome of SENS, negligible senescence, is not readily measurable in current empirical tests.
  • Proving the efficacy of SENS requires a shift in experimental design and outcome definition.
  • Current research paradigms may not be adequate to validate SENS.

Conclusions:

  • Claims for SENS require robust empirical validation beyond theoretical declarations.
  • The scientific method must be applied rigorously to aging interventions.
  • Future research should focus on developing measurable outcomes for SENS to facilitate scientific validation.