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Updated: May 18, 2026
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Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
Published on: April 4, 2025
Selective RNA versus DNA G-quadruplex targeting by in situ click chemistry
Marco Di Antonio1, Giulia Biffi, Angelica Mariani
1University of Cambridge, Department of Chemistry, Lensfield Road, Cambridge, CB2 1EW, UK.
Angewandte Chemie (International Ed. in English)
|October 6, 2012
Abstract:
It all clicks into place: A potent telomere-targeting small molecule has been identified by using the copper-free 1,3-dipolar cycloaddition of a series of alkyne and azide building blocks catalyzed by a non-Watson-Crick DNA secondary structure (see picture). This method rapidly identifies, otherwise unanticipated, potent small-molecule probes to selectively target a given RNA or DNA.
