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Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients
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Familial occurrence of chronic lymphocytic leukaemia in Norway

Geir E Tjønnfjord1, Viggo Jønsson, Bernt E Ly

  • 1Department of Haematology, Oslo University Hospital, Norway. geir.tjonnfjord@oslo-universitetssykehus.no

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|October 6, 2012
PubMed

Insights

Malignant hematological diseases, including chronic lymphocytic leukemia (CLL), are common in relatives of CLL patients. Familial occurrence significantly increases the risk of developing CLL and other lymphoproliferative diseases.

Area of Science:

  • Hematology
  • Oncology
  • Genetics

Background:

  • Chronic lymphocytic leukemia (CLL) is a cancer of the blood and bone marrow.
  • The only established risk factor for CLL is a family history of the disease.

Purpose of the Study:

  • To investigate the frequency of familial chronic lymphocytic leukemia.
  • To quantify the risk of developing CLL among relatives of affected individuals.

Main Methods:

  • Patients diagnosed with CLL between October 2007 and December 2009 were surveyed.
  • Family members reported occurrences of malignant hematological diseases.
  • Data were verified using the Cancer Registry.

Main Results:

  • 18% of CLL patients (42 of 236) had relatives with malignant hematological disease.
  • The relative risk of developing CLL was six times higher for individuals with a family history.
  • Other lymphoproliferative diseases were also more common in affected families.

Conclusions:

  • Malignant hematological diseases are frequently observed in families of CLL patients.
  • CLL is the most common familial malignancy, but other related diseases also occur.
  • Evidence suggests a potential genetic predisposition and pleiotropy in familial CLL.
Abstract

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