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Obtaining accurate p values from a dense SNP linkage scan.

William C L Stewart1, Ryan L Subaran

  • 1Battelle Center for Mathematical Medicine, Research Institute at Nationwide Children's Hospital, Columbus, Ohio 43215, USA. William.Stewart@nationwidechildrens.org

Human Heredity
|October 6, 2012
PubMed
Summary

Ignoring linkage disequilibrium (LD) in genetic studies inflates errors, mistakenly identifying neutral mutations as pathogenic. Our simulation shows a 14% error rate, highlighting the need for accurate methods like Haplodrop to control false positives in variant discovery.

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