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Updated: May 18, 2026

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Visualizing Intracellular Sialylation with Click Chemistry and Expansion Microscopy
Published on: February 7, 2025
Click and pick: identification of sialoside analogues for siglec-based cell targeting
Cory D Rillahan1, Erik Schwartz, Ryan McBride
1Department of Chemical Physiology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.
Angewandte Chemie (International Ed. in English)
|October 6, 2012
Abstract:
Click 'n' chips: Azide and alkyne-bearing sialic acids (purple diamond; see picture) were subjected to high-throughput click chemistry to generate a library of sialic acid analogues. Microarray printing of the library and screening with the siglec family of sialic-acid-binding proteins, led to the identification of high-affinity ligands for siglec-9 and siglec-10.

