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Using smell to triage samples in point-of-care assays
Hemakesh Mohapatra1, Scott T Phillips
1Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA.
Angewandte Chemie (International Ed. in English)
|October 6, 2012
Abstract:
Smell of success: Reagent 1 provides the dual readouts of odor (ethanethiol) and fluorescence (derivative of 7-hydroxycoumarin) and can be used in down-selection assays based on smell and quantitative fluorescence assays of the samples that give a positive result. An important feature of 1 is the matched sensitivity of the two outputs. This reagent is designed for use in resource-limited settings and is demonstrated in assays that detect enzymes.

