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Related Experiment Video

Updated: May 18, 2026

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
08:47

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

Published on: May 8, 2016

Pain in experimental autoimmune encephalitis: a comparative study between different mouse models.

Jianning Lu1, Martina Kurejova, Laura N Wirotanseng

  • 1Pharmacology Institut, University of Heidelberg, Im Neuenheimer Feld 366, Heidelberg, D-69120, Germany.

Journal of Neuroinflammation
|October 9, 2012
PubMed
Summary
This summary is machine-generated.

Multiple sclerosis (MS) pain mechanisms were studied in mouse models. Different models showed varied pain profiles and spinal cord changes, aiding understanding of MS pain diversity.

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Last Updated: May 18, 2026

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Area of Science:

  • Neuroscience
  • Immunology
  • Pain Research

Background:

  • Multiple sclerosis (MS) causes severe pain, but its mechanisms are poorly understood.
  • Experimental autoimmune encephalomyelitis (EAE) models offer insights into MS pathophysiology.
  • Sensory abnormalities in EAE models require thorough characterization.

Purpose of the Study:

  • To characterize hindpaw pain behavior in two distinct EAE mouse models.
  • To investigate molecular and genetic changes in the spinal cord related to pain.
  • To assess functional alterations in peripheral nerves.

Main Methods:

  • Assessed thermal and mechanical sensitivity in EAE mice throughout disease progression.
  • Conducted immunohistochemical analysis of pain and plasticity molecules in spinal cords.
  • Utilized electrophysiology to examine peripheral nerve function.

Main Results:

  • Both EAE models exhibited thermal hyperalgesia in the chronic phase.
  • SJL mice developed significant mechanical allodynia, unlike C57BL/6 mice.
  • Glial changes in the spinal cord correlated with mechanical hypersensitivity, particularly in SJL mice.

Conclusions:

  • Heterogeneous EAE models display distinct sensory and pathological changes.
  • These models facilitate the study of mechanisms underlying diverse MS pain profiles.
  • Understanding these differences is crucial for developing targeted MS pain therapies.