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Updated: May 18, 2026

A Revised Surgical Approach to Induce Endolymphatic Hydrops in the Guinea Pig
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Non-immune hydrops: Qatar experience.

Zohra Hasnani-Samnani1, Mohamed Ibrahim Mohamed Mahmoud, Ibrahim Farid

  • 1University of Calgary, Doha, Qatar.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|October 9, 2012
PubMed
Summary
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Non-immune hydrops fetalis (NIHF) is a complex condition diagnosed primarily in the second trimester. Cardiac and chromosomal abnormalities were the leading causes, with a 27% survival rate to live birth.

Area of Science:

  • Perinatology
  • Fetal Medicine
  • Neonatology

Background:

  • Non-immune hydrops fetalis (NIHF) is a serious condition characterized by excessive fluid accumulation in fetal tissues and cavities.
  • Identifying the underlying causes and predicting outcomes are crucial for effective management.

Purpose of the Study:

  • To delineate the clinical presentation, diagnostic findings, and outcomes of non-immune hydrops fetalis cases.
  • To analyze the etiological factors and survival rates in a cohort of NIHF patients.

Main Methods:

  • Retrospective chart review of 64 NIHF cases at Women's Hospital, Qatar (2003-2011).
  • Inclusion of detailed fetal scans, karyotyping, and specific investigations like MCA-PSV.
  • Analysis of maternal age, gestational age at diagnosis, presenting signs, and identified abnormalities.

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Main Results:

  • Diagnosis occurred predominantly in the second trimester (56%), with an average maternal age of 31.
  • Common signs included ascites, pleural effusion, and generalized edema.
  • Cardiac (23.43%) and chromosomal (14%) abnormalities were the most frequent identifiable causes. Survival to live birth was 27%, with 59% of these infants surviving post-delivery.

Conclusions:

  • Non-immune hydrops fetalis presents a complex diagnostic and management challenge.
  • Establishing clear follow-up protocols for NIHF cases is essential for improving patient outcomes.