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Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

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Related Experiment Video

Updated: May 18, 2026

Ultrasound Assessment of Flow-Mediated Dilation of the Brachial and Superficial Femoral Arteries in Rats
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Ultrasound Assessment of Flow-Mediated Dilation of the Brachial and Superficial Femoral Arteries in Rats

Published on: November 3, 2016

Quantification of arterial flow using digital subtraction angiography.

Odile Bonnefous1, Vitor Mendes Pereira, Rafik Ouared

  • 1Philips Research, Paris 92150, France.

Medical Physics
|October 9, 2012
PubMed
Summary

This study introduces a novel method using x-ray video densitometry to estimate arterial blood flow. The technique, validated in vitro and in clinical cases, offers accurate quantitative flow measurements for interventional procedures.

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Published on: January 7, 2019

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Last Updated: May 18, 2026

Ultrasound Assessment of Flow-Mediated Dilation of the Brachial and Superficial Femoral Arteries in Rats
09:40

Ultrasound Assessment of Flow-Mediated Dilation of the Brachial and Superficial Femoral Arteries in Rats

Published on: November 3, 2016

Two-Dimensional X-Ray Angiography to Examine Fine Vascular Structure Using a Silicone Rubber Injection Compound
05:26

Two-Dimensional X-Ray Angiography to Examine Fine Vascular Structure Using a Silicone Rubber Injection Compound

Published on: January 7, 2019

Area of Science:

  • Medical Imaging
  • Biomedical Engineering
  • Hemodynamics

Background:

  • Accurate estimation of arterial hemodynamic flow is crucial for diagnosing and treating vascular diseases.
  • Current methods for blood flow measurement may be limited in certain clinical scenarios, such as intra-cranial applications.

Purpose of the Study:

  • To propose and validate a novel method for estimating arterial hemodynamic flow using x-ray video densitometry.
  • To assess the feasibility and accuracy of this x-ray based quantitative flow estimation technique.

Main Methods:

  • Utilized three-dimensional rotational angiography and digital subtraction angiography sequences.
  • Employed an optical flow-based approach to analyze contrast density modulation by the cardiac cycle in x-ray signals.
  • Validated the method in vitro against a gold standard flow meter.

Main Results:

  • Demonstrated accurate correlation between x-ray video densitometry and flow meter measurements (ideal slope of 1 and intercept of 0 within 95% CI).
  • Achieved an accuracy of 5% for flow measurements between 2 ml/s and 6 ml/s at frame rates above 50 Hz.
  • Presented three successful clinical case applications.

Conclusions:

  • The proposed x-ray based method is feasible for estimating blood flow during routine interventional procedures.
  • This technique offers a valuable tool for quantitative flow assessment, especially in intra-cranial applications where alternatives are limited.
  • The method shows promise for enhancing clinical decision-making in interventional cardiology and radiology.