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Determining the Plane of Cell Division

Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function. 
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Updated: May 18, 2026

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging
09:56

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging

Published on: April 30, 2019

Influence of cell-to-cell variability on spatial pattern formation.

B Greese1, K Wester, R Bensch

  • 1University of Freiburg, Center for Biological Systems Analysis, Freiburg, Germany. bettina.greese@thep.lu.se

IET Systems Biology
|October 9, 2012
PubMed
Summary
This summary is machine-generated.

Cell-to-cell variations significantly impact plant trichome pattern formation, despite genetic regulation. Computer simulations reveal protein complex availability rates are key to noise-induced pattern variations, offering insights into biological pattern development.

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Area of Science:

  • Developmental Biology
  • Computational Biology
  • Plant Science

Background:

  • Spatial patterns in biology often emerge from cellular differentiation regulated by genetic networks.
  • The role of noise (random fluctuations) in genetic networks and pattern formation is not well understood.
  • Epidermal plant hairs (trichomes) provide a model system for studying pattern formation.

Purpose of the Study:

  • To investigate the variability and noise in the pattern formation of plant trichomes.
  • To understand how cell-to-cell variations influence a highly regulated differentiation process.
  • To identify key factors contributing to noise-induced variations in trichome patterns.

Main Methods:

  • Utilized local mathematical measures based on the Voronoi diagram of experimentally determined trichome positions.
  • Employed computer simulations to model pattern formation and noise effects.
  • Focused on analyzing cell-to-cell variations and their impact on pattern regularity.

Main Results:

  • Experimentally observed trichome patterns are substantially disturbed by cell-to-cell variations.
  • Rates of protein complex availability, which triggers trichome formation, significantly influence noise-induced pattern variations.
  • Cellular noise plays a crucial role in the observed variability of trichome patterns.

Conclusions:

  • Cell-to-cell variations are a significant factor in the spatial patterning of plant trichomes.
  • Understanding the dynamics of protein complex availability is essential for explaining noise in pattern formation.
  • The study's approach can be applied to investigate noise in other biological differentiation processes.