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JBIR-129 and -139, cytotoxic 34-membered polyol macrolides of microbial origin
Teppei Kawahara1, Ji-Hwan Hwang, Miho Izumikawa
1Japan Biological Informatics Consortium-JBIC, 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan.
Abstract:
New 34-membered polyol macrolides JBIR-129 (1) and JBIR-139 (2) were isolated from the culture of the terrestrial Streptomyces RK74. The planar structures of 1 and 2 were established on the basis of 1D and 2D NMR, ESI-TOF-MS, IR, and UV spectra. The relative configurations of the sugar units were determined by analyzing vicinal ¹H-¹H coupling constants and steric information. Both 1 and 2 showed cytotoxic activity against human ovarian adenocarcinoma SKOV-3 cells with IC₅₀ values of 0.3 and 0.4 μM, respectively.
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