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Updated: May 18, 2026

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)
Published on: August 4, 2023
[Diagnosis and treatment of trauma-induced coagulopathy]
J-S David1, A Roumagnac, É Rulliat
1Service d'anesthésie-réanimation, centre hospitalier Lyon Sud, hospices civils de Lyon, chemin du Grand-Revoyet, 69495 Pierre-Bénite cedex, France. jean-stephane.david@chu-lyon.fr
Abstract:
Trauma-induced coagulopathy is frequent and complex, and is responsible for an impairment of trauma outcome. Diagnosis of trauma coagulopathy is usually done with standard biology but recently new technics arose and gave us the opportunity to have faster information on coagulopathy with quick INR measure or clot formation study with thrombelastometry. Treatment of the coagulopathy should be done earlier in the course of trauma. Two strategies are possible that include either the association of RBC, platelet and FFP in a predefined ratio, or the use of factor concentrates guided with thrombelastometry. Treatment of favouring factors such as hypothermia, acidosis and hypocalcemia is also mandatory.
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