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Related Experiment Video

Updated: May 18, 2026

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model
13:04

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Published on: March 18, 2015

Tissue engineered vascular grafts--preclinical aspects.

Lynda V Thomas1, Lekshmi V, Prabha D Nair

  • 1Division of Tissue Engineering and Regeneration Technologies, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Kerala 695012, India.

International Journal of Cardiology
|October 9, 2012
PubMed
Summary

Preclinical evaluation techniques are crucial for developing safe and effective tissue-engineered vascular grafts (TEVG). This review highlights strategies, animal models, and in vivo studies for advancing regenerative vascular therapies.

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Vascular Surgery

Background:

  • Tissue engineering aims to create biological vascular substitutes that mimic natural tissue function.
  • Developing effective preclinical evaluation techniques is essential for the clinical translation of tissue-engineered vascular grafts (TEVG).

Purpose of the Study:

  • To review preclinical studies on tissue-engineered vascular grafts (TEVG).
  • To highlight strategies, animal models, and in vivo evaluation methods for TEVG development.
  • To emphasize the interdisciplinary collaboration needed for advancing regenerative vascular therapies.

Main Methods:

  • Literature review of preclinical studies on TEVG.
  • Analysis of different cell and scaffold strategies.
Keywords:
Animal modelsPre clinical evaluationScaffoldsTissue engineeringVascular graft

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Last Updated: May 18, 2026

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model
13:04

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Published on: March 18, 2015

Scaling of Engineered Vascular Grafts Using 3D Printed Guides and the Ring Stacking Method
09:38

Scaling of Engineered Vascular Grafts Using 3D Printed Guides and the Ring Stacking Method

Published on: March 27, 2017

Implantation of Inferior Vena Cava Interposition Graft in Mouse Model
12:39

Implantation of Inferior Vena Cava Interposition Graft in Mouse Model

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  • Examination of animal models and in vivo evaluation techniques.

    • Main Results:

    • Various preclinical strategies for TEVG development have been explored.
    • Different animal models are utilized for in vivo assessment.
    • In vivo studies are critical for evaluating TEVG safety and efficacy.

    Conclusions:

    • Robust preclinical evaluation is necessary for the clinical application of TEVG.
    • Interdisciplinary collaboration among engineers, biologists, and clinicians is vital.
    • Advancements in TEVG hold significant promise for regenerative therapy.