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Apolipoprotein E and familial longevity.

Nicole Schupf1, Sandra Barral, Thomas Perls

  • 1Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA. ns24@columbia.edu

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|October 9, 2012
PubMed
Summary
This summary is machine-generated.

Genes influencing longevity were studied in long-lived families. Reduced frequency of the apolipoprotein E (APOE) ε4 allele and increased frequency of the APOE ε2 allele were linked to exceptional lifespan.

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Area of Science:

  • Genetics
  • Gerontology
  • Molecular Biology

Background:

  • Exceptional longevity exhibits significant heritability.
  • Specific alleles of apolipoprotein E (APOE) and TOMM40 have been inconsistently linked to mortality.
  • Understanding genetic factors is crucial for aging research.

Purpose of the Study:

  • To investigate the association of APOE and TOMM40 genetic variants with longevity in offspring from long-lived families.
  • To compare allele frequencies between individuals with exceptional longevity and controls.

Main Methods:

  • Recruitment of offspring from long-lived families and spouse controls across three sites.
  • Utilized generalized estimating equations for statistical analysis.
  • Adjusted for covariates including age, sex, education, and family membership.

Main Results:

  • Offspring from long-lived families showed a lower likelihood of carrying the APOE ε4 allele (OR, 0.75; p=0.005) and the TOMM40 rs2075650 G allele (OR, 0.70; p=0.002).
  • Conversely, these individuals had a higher likelihood of carrying the APOE ε2 allele (OR, 1.5; p=0.007).

Conclusions:

  • Findings support the role of reduced APOE ε4 and increased APOE ε2 allele frequencies in contributing to exceptional longevity.
  • These genetic variations may be key determinants of lifespan in specific populations.