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Related Experiment Video

Updated: May 18, 2026

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale

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Published on: July 8, 2025

Brivudin induced delirium: a case report.

Ibak Gonen¹, Hakan Turan, Davud Ozdemir

¹Department of Infectious Diseases, School of Medicine, University of Duzce, Duzce, Turkey. dribak77@hotmail.com

Journal of Chemotherapy (Florence, Italy)

|October 9, 2012

Summary

Brivudin, an antiviral for herpes zoster, may cause delirium. This rare side effect resolved after stopping the medication, highlighting the importance of clinician awareness for patient recovery.

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Area of Science:

Pharmacology
Neurology
Infectious Diseases

Background:

Brivudin is an oral antiviral medication prescribed for herpes zoster (shingles) infections.
Commonly reported side effects include nausea and headache.
The safety profile of brivudin is generally well-established for its intended use.

Observation:

This case report details a patient experiencing delirium during brivudin treatment for herpes zoster.
The onset of delirium occurred after four days of medication use.
The patient's symptoms significantly improved upon discontinuation of brivudin.

Findings:

Delirium is identified as a potential, previously unreported adverse effect of brivudin.
Cessation of brivudin treatment led to the complete remission of the delirium.
This suggests a direct link between brivudin and the observed neurological side effect.

Implications:

Clinicians prescribing brivudin should be vigilant for potential neurological side effects like delirium.
Awareness of this adverse event can guide prompt diagnosis and management.
Early recognition and drug cessation are likely to result in full clinical recovery for affected patients.