Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's phenomenon, is a...
Alterations in Blood Pressure01:30

Alterations in Blood Pressure

Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart beats)...
Blood Pressure Imbalances and Circulatory Shock01:24

Blood Pressure Imbalances and Circulatory Shock

Disorders affecting blood volume, vascular tone, or vascular function can disrupt vascular homeostasis, including conditions like hypertension, hemorrhage, and shock.
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
Neural Regulation of Blood Pressure01:18

Neural Regulation of Blood Pressure

The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial: Exercise and menopause: benefits, challenges and the transition to optimal management.

Frontiers in sports and active living·2026
Same author

Bacteria deliver a microtubule-binding protein into mammalian cells to promote colonization.

Science (New York, N.Y.)·2026
Same author

The cutaneous sympathetic blockade associated with labour epidural analgesia. Response to Br J Anaesth 2026; 136: 388-9.

British journal of anaesthesia·2026
Same author

The cutaneous sympathetic blockade associated with labour epidural analgesia: a quasi-experimental study conducted during labour and after delivery.

British journal of anaesthesia·2025
Same author

Getting under the skin of the menopausal hot flush: a protocol to examine skin function and structure in symptomatic postmenopausal women.

Frontiers in global women's health·2025
Same author

Validation of a novel method to quantify local axilla sweating, SweatSENSE.

Journal of thermal biology·2025

Related Experiment Video

Updated: May 18, 2026

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
14:09

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance

Published on: March 21, 2013

Exercise-induced hypotension in autonomic disorders.

David A Low1, Antonio C L da Nóbrega, Christopher J Mathias

  • 1Autonomic and Neurovascular Medicine Unit, Department of Medicine, Division of Brain Sciences, Faculty of Medicine, Imperial College London at St Mary's Hospital, UK.

Autonomic Neuroscience : Basic & Clinical
|October 9, 2012
PubMed
Summary

Exercise induced hypotension, a significant drop in blood pressure during physical activity, impacts patients with autonomic failure. This condition, linked to reduced sympathetic nerve activity, impairs physical capacity and quality of life.

Related Experiment Videos

Last Updated: May 18, 2026

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
14:09

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance

Published on: March 21, 2013

Area of Science:

  • Cardiovascular Physiology
  • Autonomic Nervous System Function
  • Exercise Physiology

Background:

  • The autonomic nervous system regulates vital functions, including cardiovascular control.
  • Physical activity necessitates coordinated autonomic and cardiovascular adjustments for homeostasis.
  • Autonomic nervous system dysfunction, like autonomic failure, can impair blood pressure control, leading to hypotension.

Purpose of the Study:

  • To define exercise induced hypotension and its clinical significance.
  • To explore the underlying mechanisms of exercise induced hypotension.
  • To review potential management strategies for exercise induced hypotension.

Main Methods:

  • Literature review on autonomic nervous system function during exercise.
  • Analysis of physiological responses in patients with autonomic disorders.
  • Examination of clinical implications and management approaches.

Main Results:

  • Exercise induced hypotension is defined as a ≥ 10 mmHg fall in systolic blood pressure during exercise.
  • This condition is a significant concern for patients with autonomic failure, Multiple System Atrophy, and Spinal Cord Injury.
  • Likely mechanisms involve blunted sympathetic nerve activity and/or excessive splanchnic vasodilation, not altered cardiac output or muscle vasodilation.
  • Dynamic exercise appears to induce more severe hypotension than static exercise.

Conclusions:

  • Exercise induced hypotension poses significant risks, reducing physical capacity and quality of life.
  • Management may involve non-pharmacological and pharmacological approaches, though research on the latter is limited.