Control of minicell producing cell division by cAMP-receptor protein complex in Escherichia coli

It has been established that the strain CA8000 of Escherichia coli K12 produces minicells. This phenotype of CA8000 has been shown to be suppressed by additional mutations in cya or crp genes. Minicell production by cya+ crp+ min bacteria is probably a consequence of error, introduced by horizontal growth, in the selection of site on the envelope for initiation of hemispherical growth.