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Related Concept Videos

Drug Dependence01:17

Drug Dependence

Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids01:24

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its effects by...
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...
Hallucinogens and Psychedelics01:27

Hallucinogens and Psychedelics

Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains delta-9-tetrahydrocannabinol (THC)...
CNS Depressants: Alcohol and Nicotine01:27

CNS Depressants: Alcohol and Nicotine

Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...

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Related Experiment Video

Updated: May 18, 2026

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
07:51

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

[Cannabis: Use and dependence].

Alain Dervaux1, Xavier Laqueille

  • 1Centre hospitalier Sainte-Anne, service d'addictologie Moreau-de-Tours, 75014 Paris, France. a.dervaux@ch-sainte-anne.fr

Presse Medicale (Paris, France : 1983)
|October 9, 2012
PubMed
Summary
This summary is machine-generated.

Cannabis dependence involves craving, impaired control, and withdrawal symptoms like insomnia and irritability. Treatment focuses on behavioral therapies, as no specific medications exist for cannabis use disorder.

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Related Experiment Videos

Last Updated: May 18, 2026

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Published on: August 1, 2025

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Published on: August 18, 2020

Development of a Preclinical Inhalation Model to Test Vaporized Cannabis Distillates
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Area of Science:

  • Addiction Medicine
  • Neuroscience
  • Psychiatry

Context:

  • Cannabis dependence is a significant public health concern.
  • Understanding the multifaceted nature of cannabis use disorder is crucial for effective intervention.
  • Co-occurring substance use and psychiatric disorders are common in individuals with cannabis dependence.

Purpose:

  • To outline the key characteristics, withdrawal symptoms, and cognitive impairments associated with cannabis dependence.
  • To review the frequent psychiatric and substance use comorbidities.
  • To discuss current treatment approaches and the lack of pharmacological interventions.

Summary:

  • Cannabis dependence is characterized by craving, loss of control over use, and significant life impairment.
  • Withdrawal symptoms include insomnia, irritability, and mood disturbances, while cognitive deficits affect attention and memory.
  • Commonly co-occurs with alcohol/substance abuse and psychiatric conditions like anxiety and mood disorders.
  • Treatment relies on behavioral psychotherapies such as motivational interviewing and cognitive-behavioral therapy.
  • No specific pharmacological treatments are currently available for cannabis dependence or withdrawal.

Impact:

  • Informs clinicians about the comprehensive management of cannabis dependence.
  • Highlights the need for integrated treatment of co-occurring conditions.
  • Emphasizes the current limitations in pharmacological treatment options, guiding future research directions.