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Related Concept Videos

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
In Vitro Drug Dissolution: Alternative Methods01:17

In Vitro Drug Dissolution: Alternative Methods

Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...

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Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
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Published on: September 20, 2017

Fast dissolving eutectic compositions of curcumin.

N Rajesh Goud1, Kuthuru Suresh, Palash Sanphui

  • 1School of Chemistry, University of Hyderabad, Prof. C. R. Rao Road, Gachibowli, Central University P.O., Hyderabad 500 046, India.

International Journal of Pharmaceutics
|October 9, 2012
PubMed
Summary
This summary is machine-generated.

Researchers enhanced curcumin solubility by creating eutectic mixtures with coformers like nicotinamide. This improved curcumin

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Area of Science:

  • Pharmaceutical Science
  • Materials Science
  • Herbal Medicine

Background:

  • Curcumin, a bioactive herbal compound, suffers from poor solubility, limiting its therapeutic applications.
  • Developing novel solid-state forms is crucial for enhancing curcumin's bioavailability and efficacy.

Purpose of the Study:

  • To discover high-solubility solid-state forms of curcumin using pharmaceutically acceptable coformers.
  • To investigate the formation and characterization of curcumin-coformer eutectic compositions.

Main Methods:

  • Mechano-chemical grinding of curcumin with various coformers (nicotinamide, ferulic acid, hydroquinone, p-hydroxybenzoic acid, l-tartaric acid).
  • Characterization using differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), IR-Raman spectroscopy, and solid-state NMR spectroscopy.

Main Results:

  • Successfully prepared binary eutectic compositions of curcumin with nicotinamide (1:2), ferulic acid (1:1), hydroquinone (1:1), p-hydroxybenzoic acid (1:1), and l-tartaric acid (1:1).
  • Confirmed the eutectic nature and absence of cocrystal/salt formation through spectroscopic and thermal analyses.
  • The curcumin-nicotinamide (CUR-NAM) eutectic demonstrated a 10-fold increase in intrinsic dissolution rate (IDR) and a 6-fold higher area under the curve (AUC) compared to crystalline curcumin.

Conclusions:

  • Eutectic mixtures offer a viable strategy to significantly enhance the solubility and bioavailability of curcumin.
  • The developed curcumin-nicotinamide eutectic composition shows promising potential for improved therapeutic outcomes.