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Related Concept Videos

Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Telomeres and Telomerase02:41

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
Telomeres and Telomerase02:41

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
Replication in Eukaryotes01:29

Replication in Eukaryotes

In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Replication in Eukaryotes02:31

Replication in Eukaryotes

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Updated: May 18, 2026

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

How "reversible" is telomeric aging?

Elissa Epel1

  • 1University of California, San Francisco, San Francisco, CA 94143, USA. EEpel@lppi.ucsf.edu

Cancer Prevention Research (Philadelphia, Pa.)
|October 9, 2012
PubMed
Summary
This summary is machine-generated.

Telomere length, a marker of biologic aging, can be influenced by lifestyle and stress. Behavioral interventions show promise in slowing or reversing cell aging by affecting telomere maintenance.

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Area of Science:

  • Cellular biology
  • Gerontology
  • Genetics

Background:

  • Telomere length is a predictor of cancer, immune, and metabolic diseases.
  • The telomere/telomerase system is implicated in biologic aging and disease processes.
  • Factors influencing telomere length include genetics, prenatal conditions, early adversity, stress, and lifestyle.

Purpose of the Study:

  • To review current understanding of telomere lengthening.
  • To explore the malleability of telomere length through behavioral interventions.
  • To discuss mechanisms of telomere lengthening and future research needs.

Main Methods:

  • Review of existing literature on telomere length and aging.
  • Discussion of findings from small-scale stress reduction and wellness studies.
  • Exploration of potential mechanisms for telomere lengthening (telomerase-mediated and pseudo-lengthening).

Main Results:

  • Small-scale studies suggest cell aging can be slowed or reversed in vivo.
  • Promising findings indicate potential for behavioral interventions to impact telomere length.
  • Mechanisms may involve direct telomere elongation or changes in cell type distribution.

Conclusions:

  • Telomere length is potentially malleable through behavioral interventions.
  • Further translational research is needed to understand mechanisms.
  • Well-designed intervention studies are crucial for understanding clinical implications.