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Lobarin from the Sumatran lichen, Stereocaulon halei
Friardi Ismed1, Françoise Lohézic-Le Dévéhat, Olivier Delalande
1UMR CNRS 6226 ISCR, Equipe PNSCM, Faculté des Sciences Pharmaceutiques et Biologiques, Univ. Rennes 1, 35043 Rennes Cedex, France.
Abstract:
The diphenyl ether, lobarin (1) (syn. lobariol carboxylic acid) related to lobaric acid was isolated for the first time as a natural product along with five known compounds from Stereocaulon halei, a fruticose lichen collected in Indonesia. The structure of lobarin was elucidated by spectroscopic data analysis and its most stable conformers were determined by molecular mechanic dynamic calculations. A marked superoxide anion scavenging was found for compound 1 while no cytotoxicity on the B16 murine melanoma and HaCaT human keratinocyte cell lines was observed.
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