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Updated: May 18, 2026

Effects of Mindfulness Training Combined with Tai Chi in Patients with Diabetic Peripheral Neuropathy
Published on: July 14, 2023
Diabetes increases mechanical sensitivity and causes morphological abnormalities in the sural nerve that are
Patrícia Severo Do Nascimento1, Gisele Agustini Lovatel, Jocemar Ilha
1Programa de Pós-Graduaç˜o em Neurociências, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Introduction:
In this investigation we evaluated the effects of treadmill training on mechanical sensitivity and sural nerve morphology in diabetic rats.
Methods:
Rats were divided into 3 groups: control (C); diabetic (D); and trained diabetic (TD). Training was performed for 8 weeks. Mechanical sensitivity was evaluated using von Frey filaments. Sural nerve analysis included fiber area, diameter, density of myelinated fibers, area occupied by connective tissue, myelin sheath thickness, and g-ratio.
Results:
Animals in the D group had a reduced mechanical sensitivity threshold. Morphometric study showed that the D group had a smaller myelinated fiber area and diameter, higher density of fibers and area occupied by connective tissue, thinner myelin sheath, and higher g-ratio. The D group had a higher percentage of small myelinated fibers and a lower percentage of large-diameter myelinated fibers than the C and TD groups.
Conclusion:
Training prevents functional and morphological abnormalities in the sural nerve caused by diabetes.
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