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Published on: July 14, 2016
[Association study between age-related macular degeneration and R1210C mutation of CFH gene in Chinese population]
Si-kui Shen1, Xiao-qi Liu, Fang Lu
1West China School of Medicine, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Objective:
A R1210C mutation of complement factor H (CFH) gene has been associated with age-related macular degeneration (AMD) in Caucasian population. This study was to verify above association in Han Chinese population.
Methods:
The mutation was detected by direct sequencing in 258 patients with wet AMD and 426 matched controls.
Results:
The R1210C mutation has not been identified in either sample.
Conclusion:
The R1210C mutation in CFH gene is not associated with AMD in Han Chinese population.
