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Surgical Model for Single-Staged Tissue-Engineered Urothelial Tubes in Minipigs
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Tissue engineering in urethral reconstruction--an update.

Altaf Mangera1, Christopher R Chapple

  • 1Department of Urology Research, Sheffield Teaching Hospitals NHS Trust, Royal Hallamshire Hospital, Sheffield S10 2JF, UK.

Asian Journal of Andrology
|October 9, 2012
PubMed
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Tissue engineered urethral grafts show promise for treating urethral strictures. Researchers are exploring cell-free and cell-seeded options to reduce donor site morbidity and improve patient outcomes.

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Urology

Background:

  • Tissue engineering is advancing, with significant efforts focused on creating urethral grafts.
  • Current grafts can lead to donor site morbidity, especially for longer replacements.
  • Oral mucosa substitution urethroplasty is a current treatment for urethral strictures.

Purpose of the Study:

  • To evaluate the progress in developing tissue engineered urethral grafts.
  • To review different approaches for creating these grafts.
  • To assess the success of these grafts in human studies.

Main Methods:

  • Investigation of cell-free tissue engineered grafts.
  • Investigation of cell-seeded tissue engineered grafts.
  • Review of human studies on urethral graft success.

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Last Updated: May 18, 2026

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Published on: July 5, 2024

Urethroplasty with Pedicled Tunica Vaginalis for the Treatment of Long-segment Anterior Urethral Stricture Caused by Lichen Sclerosus of Glans Penis
03:55

Urethroplasty with Pedicled Tunica Vaginalis for the Treatment of Long-segment Anterior Urethral Stricture Caused by Lichen Sclerosus of Glans Penis

Published on: October 18, 2024

Main Results:

  • Both cell-free and cell-seeded approaches have been explored.
  • Various methods for graft development have been reported.
  • Successes in human studies indicate potential clinical applicability.

Conclusions:

  • Tissue engineered urethral grafts offer a potential alternative to current treatments.
  • Further research is needed to optimize graft performance.
  • These grafts may improve management of extensive urethral strictures.