Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serum cortisol abnormalities after craniocerebral trauma.

P Steinbok, G Thompson

    Neurosurgery
    |November 1, 1979
    PubMed
    Summary

    Serum cortisol abnormalities, including altered diurnal rhythm and elevated levels, are common in patients with craniocerebral trauma. These changes correlate with head injury severity and suggest a modified feedback mechanism, not a complete failure.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Bone-conduction hearing implants: a potential postcode lottery.

    Annals of the Royal College of Surgeons of England·2025
    Same author

    Mixed methods evaluation of a digital resource to build students' skills in ASsessing cardiovascular risk, MOtivating change, and SUStaining a healthier lifestyle in themselves and others- ASMOSUS: a study protocol.

    BMC nursing·2025
    Same author

    The role of a mobile hearing application in secondary care ENT (HAppENT).

    The Journal of laryngology and otology·2024
    Same author

    The Scottish Brain Health Service Model: Rationale and Scientific Basis for a National Care Pathway of Brain Health Services in Scotland.

    The journal of prevention of Alzheimer's disease·2022
    Same author

    How I do it: intracapsular coblation tonsillectomy.

    The Journal of laryngology and otology·2022
    Same author

    Correction of artefacts associated with large area EBSD.

    Ultramicroscopy·2021

    Area of Science:

    • Neuroendocrinology
    • Trauma Medicine
    • Clinical Chemistry

    Background:

    • Craniocerebral trauma can significantly impact endocrine function.
    • Alterations in serum cortisol levels are a potential consequence of severe head injury.
    • Understanding the hypothalamic-pituitary-adrenal (HPA) axis response is crucial in managing traumatic brain injury.

    Purpose of the Study:

    • To investigate the prevalence and nature of serum cortisol abnormalities in patients with craniocerebral trauma.
    • To correlate cortisol changes with the severity of head injury.
    • To assess the integrity of the feedback mechanism regulating cortisol production post-trauma.

    Main Methods:

    • Serial measurements of serum cortisol were conducted in 49 patients with craniocerebral trauma.
    • Diurnal rhythm and serum cortisol levels were analyzed.
    • Dexamethasone suppression tests were performed in a subset of patients to evaluate feedback mechanisms.

    Main Results:

    • Twenty-one out of 49 patients exhibited abnormalities in serum cortisol, including altered diurnal patterns and elevated levels.
    • The frequency and severity of cortisol abnormalities correlated with head injury severity.
    • Middle fossa basal skull fractures showed a trend towards predisposing to cortisol abnormalities.
    • Dexamethasone successfully suppressed elevated serum cortisol levels in all tested patients.

    Conclusions:

    • Hypercortisolemia following head injury appears to result from an altered, rather than abolished, feedback mechanism.
    • The HPA axis remains responsive to external regulation (dexamethasone) despite trauma-induced changes.
    • Monitoring serum cortisol may provide insights into the neuroendocrine response to craniocerebral trauma.

    Related Experiment Videos