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Updated: May 18, 2026

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
Genomic dysregulation in gastric tumors
Yelena Y Janjigian1, David P Kelsen
1Department of Medicine, Gastrointestinal Oncology Service, Memorial Sloan-Kettering Cancer Center, Weill Cornell Medical College of Cornell University, New York, New York 10065, USA. janjigiy@mskcc.org
Abstract:
Gastric cancer is among the most common human malignancies and the second leading cause of cancer-related death. The different epidemiologic and histopathology of subtypes of gastric cancer are associated with different genomic patterns. Data suggests that gene expression patterns of proximal, distal gastric cancers-intestinal type, and diffuse/signet cell are well separated. This review summarizes the genetic and epigenetic changes thought to drive gastric cancer and the emerging paradigm of gastric cancer as three unique disease subtypes.
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