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Related Concept Videos

Inflammation01:38

Inflammation

Overview
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
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Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
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Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...

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Related Experiment Video

Updated: May 18, 2026

Isolation of Macrophage Subsets and Stromal Cells from Human and Mouse Myocardial Specimens
07:25

Isolation of Macrophage Subsets and Stromal Cells from Human and Mouse Myocardial Specimens

Published on: December 17, 2019

Macrophages modulate cardiac function in lipotoxic cardiomyopathy.

Joel D Schilling1, Heather M Machkovech, Alfred H J Kim

  • 1Diabetic Cardiovascular Disease Center, Washington University School of Medicine, St. Louis, MO 63110, USA.

American Journal of Physiology. Heart and Circulatory Physiology
|October 9, 2012
PubMed
Summary

Inflammation and macrophage infiltration in the heart contribute to diabetic cardiomyopathy. Reducing these inflammatory responses can improve cardiac function in diabetes.

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Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
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Last Updated: May 18, 2026

Isolation of Macrophage Subsets and Stromal Cells from Human and Mouse Myocardial Specimens
07:25

Isolation of Macrophage Subsets and Stromal Cells from Human and Mouse Myocardial Specimens

Published on: December 17, 2019

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

Area of Science:

  • Cardiovascular Biology
  • Metabolic Diseases
  • Molecular Cardiology

Background:

  • Diabetes mellitus is linked to myocardial lipid accumulation and heart failure.
  • The mechanisms underlying diabetic lipotoxic cardiomyopathy remain unclear.
  • Inflammation is increasingly recognized as a key factor in diabetes and lipid excess.

Purpose of the Study:

  • To investigate the role of inflammatory activation in lipotoxic cardiomyopathy.
  • To explore the impact of inflammation on cardiac dysfunction in a mouse model of diabetes.

Main Methods:

  • Utilized a transgenic mouse model (MHC-ACS) with cardiac-specific overexpression of long-chain acylCoA synthetase 1.
  • Assessed inflammatory cytokine levels and macrophage infiltration in the myocardium.
  • Administered liposomal clodronate to deplete macrophages.

Main Results:

  • Upregulation of inflammatory cytokines and macrophage infiltration preceded cardiac dysfunction in MHC-ACS mice.
  • Macrophage depletion significantly reduced cardiac inflammation and improved cardiac function.
  • Early inflammatory responses are implicated in adverse cardiac remodeling.

Conclusions:

  • Early inflammatory activation and macrophage recruitment play a critical role in the pathogenesis of lipotoxic cardiomyopathy.
  • Targeting inflammation may offer a therapeutic strategy for heart failure in diabetes and obesity.