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Increased coagulation in childhood obesity

Yildiz Dallar Bilge1, Bulent Alioglu, Enver Simşek

  • 1Department of Pediatrics, Ankara Training and Research Hospital, Ankara, Turkey.

Pediatric Hematology and Oncology
|October 10, 2012
PubMed

Insights

Childhood obesity is linked to increased blood clotting factors and decreased clot-dissolving factors. This suggests potential endothelial dysfunction in obese children, warranting further investigation.

Area of Science:

  • Hematology
  • Pediatric Endocrinology
  • Cardiovascular Health

Background:

  • Childhood obesity is a growing global health concern.
  • Obesity is associated with increased risk of thrombotic events.
  • The impact of childhood obesity on the coagulation system requires further elucidation.

Purpose of the Study:

  • To investigate the relationship between childhood obesity and the procoagulant and anticoagulant systems.
  • To compare coagulation parameters in obese children versus healthy controls.

Main Methods:

  • Recruited 51 obese and 32 normal-weighted children (ages 5-16).
  • Recorded anthropometric measures, comorbidities, and medication history.
  • Performed complete blood counts and assessed procoagulant and anticoagulant factors.

Main Results:

  • Obese children showed higher erythrocyte hemoglobin, erythrocyte distribution width, and platelet counts.
  • Elevated levels of fibrinogen, thrombin time, Factor VIII, Factor IX, Factor X, and von Willebrand factor were observed in obese children.
  • Antithrombin levels were significantly lower in obese children compared to controls.

Conclusions:

  • Obese children exhibit a procoagulant state with reduced anticoagulant activity.
  • Increased plasma procoagulant factors suggest potential endothelial activity in obese children.
  • Further research into endothelial function in pediatric obesity is recommended.
Abstract

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