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Updated: May 18, 2026
09:36
Assessment of Child Anthropometry in a Large Epidemiologic Study
Published on: February 2, 2017
Increased coagulation in childhood obesity
Yildiz Dallar Bilge1, Bulent Alioglu, Enver Simşek
1Department of Pediatrics, Ankara Training and Research Hospital, Ankara, Turkey.
Pediatric Hematology and Oncology
|October 10, 2012
Summary
Childhood obesity is linked to increased blood clotting factors and decreased clot-dissolving factors. This suggests potential endothelial dysfunction in obese children, warranting further investigation.
Area of Science:
- Hematology
- Pediatric Endocrinology
- Cardiovascular Health
Background:
- Childhood obesity is a growing global health concern.
- Obesity is associated with increased risk of thrombotic events.
- The impact of childhood obesity on the coagulation system requires further elucidation.
Purpose of the Study:
- To investigate the relationship between childhood obesity and the procoagulant and anticoagulant systems.
- To compare coagulation parameters in obese children versus healthy controls.
Main Methods:
- Recruited 51 obese and 32 normal-weighted children (ages 5-16).
- Recorded anthropometric measures, comorbidities, and medication history.
- Performed complete blood counts and assessed procoagulant and anticoagulant factors.
Main Results:
- Obese children showed higher erythrocyte hemoglobin, erythrocyte distribution width, and platelet counts.
- Elevated levels of fibrinogen, thrombin time, Factor VIII, Factor IX, Factor X, and von Willebrand factor were observed in obese children.
- Antithrombin levels were significantly lower in obese children compared to controls.
Conclusions:
- Obese children exhibit a procoagulant state with reduced anticoagulant activity.
- Increased plasma procoagulant factors suggest potential endothelial activity in obese children.
- Further research into endothelial function in pediatric obesity is recommended.
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