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Updated: May 18, 2026

Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
Humalog (lispro) for type 2 diabetes.
Katherine Esposito1, Annalisa Capuano, Dario Giugliano
1Second University of Naples, Department of Cardio-thoracic and Respiratory Sciences, Piazza L. Miraglia 2, 80138 Naples, Italy. katherine.esposito@unina2.it
Insulin therapy, particularly insulin lispro, is highly effective for managing type 2 diabetes when other medications fail. Insulin lispro offers advantages in glucose control and treatment flexibility.
Area of Science:
- Endocrinology
- Pharmacology
- Diabetes Mellitus Research
Background:
- Type 2 diabetes is a progressive condition requiring insulin therapy for optimal glycemic control.
- Insulin treatment is crucial for managing hyperglycemia in advanced type 2 diabetes.
Purpose of the Study:
- To review the efficacy and safety of insulin lispro in type 2 diabetes patients.
- To analyze randomized controlled trials (RCTs) evaluating insulin lispro.
Main Methods:
- Literature search of PubMed from January 1990 to May 2012.
- Inclusion of RCTs assessing insulin lispro in type 2 diabetes.
Main Results:
- Insulin is the most effective therapy for significant HbA1c reduction (≥1.5%).
- Insulin lispro analogues show pharmacokinetic and pharmacodynamic advantages over human insulin.
- Insulin lispro protamine suspension (ILPS) demonstrates comparable glucose control and hypoglycemia risk to other insulins, with potential for lower doses.
Conclusions:
- Insulin lispro analogues offer benefits over human insulin.
- Premixed lispro/ILPS formulations allow for pre-meal injection, enhancing treatment flexibility.
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