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Songaricalarins A-E, cytotoxic oplopane sesquiterpenes from Ligularia songarica
Qi Wang1, Tzu-Hsuan Chen, Kenneth F Bastow
1Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, People's Republic of China.
Abstract:
Five new highly oxygenated oplopane sesquiterpenes, songaricalarins A-E (1-5), and two known analogues (6 and 7) were isolated from the roots and rhizomes of Ligularia songarica. Their structures and configurations were elucidated by spectroscopic methods, including 2D-NMR techniques, and the structure of 1 was confirmed by single-crystal X-ray diffraction. All compounds were evaluated for in vitro cytotoxic activity against cultured A-549, MCF-7, KB, and KBVIN cells, and 4 exhibited cytotoxicity with EC50 values of 4.9, 0.8, 3.4, and 3.2 μg/mL, respectively.
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