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An improved method for bonding heparin to intravascular cannulae
A J Freeman1, C J Gardner, M G Dodds
1Cardiovascular Pharmacology Department, Glaxo Group Research, Ltd., Greenford, Middlesex, United Kingdom.
Journal of Pharmacological Methods
|March 1, 1990
Summary
Improving intravascular cannulae patency involves bonding heparin to reduce thrombus formation. A novel heparin-bonding treatment significantly extended cannula patency in rat models, offering a promising solution for medical devices.
Area of Science:
- Biomedical Engineering
- Materials Science
- Thrombosis Research
Background:
- Chronic implantation of intravascular cannulae is often limited by thrombus formation at the cannula tip, compromising device function and patient outcomes.
- Developing effective antithrombotic strategies for implanted medical devices is crucial for improving their longevity and efficacy.
Purpose of the Study:
- To evaluate novel heparin-bonding treatments for improving the antithrombotic properties of chronically implanted intravascular cannulae.
- To assess the efficacy of these treatments in extending cannula patency in a relevant animal model.
Main Methods:
- Intravascular cannulae were subjected to various heparin-bonding treatments, including a tridodecylmethylammonium chloride-heparin-glutaraldehyde procedure.
- Cannula patency was evaluated in a chronically cannulated rat thoracic aorta model, measuring the duration of patency before occlusion by thrombus.
Main Results:
- Heparin-bonded cannulae demonstrated significantly improved patency compared to untreated controls.
- The tridodecylmethylammonium chloride-heparin-glutaraldehyde treatment resulted in the longest mean patency, averaging 13.3 days versus 4.0 days for untreated cannulae.
Conclusions:
- Heparin-bonding is an effective method for enhancing the antithrombotic properties of intravascular cannulae.
- The tridodecylmethylammonium chloride-heparin-glutaraldehyde technique offers a simple and effective approach to significantly extend cannula patency, reducing complications associated with thrombus formation.