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De novo Ph negative T-cell lymphoblastic leukaemia associated with bcr gene rearrangement
P G Middleton1, E V Davison, M M Reid
1Department of Haematology, University of Newcastle upon Tyne, England.
Leukemia Research
|January 1, 1990
Abstract:
One case of de novo Ph-negative T-cell acute lymphoblastic leukaemia has been found to have a classical breakpoint cluster region (bcr) rearrangement of the type seen in chronic granulocytic leukaemia. There were no haematological features to suggest a previous chronic phase. This case represents the first report of this rearrangement in Ph negative acute T-lymphoblastic leukaemia at presentation. The implications for various therapeutic options in such patients are discussed.