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A review of dietary interventions in autism.

Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists·2009
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Paradigms for Behavioral Assessment in Drosophila Model of Autism Spectrum Disorder
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Modeling autism: a systems biology approach.

Mary Randolph-Gips1, Pramila Srinivasan

  • 1Systems Engineering and Computer Engineering, University of Houston - Clear Lake, 2700 Bay Area Bvd, Houston, TX, 77058, USA. randolph-gips@uhcl.edu.

Journal of Clinical Bioinformatics
|October 10, 2012
PubMed
Summary

Autism spectrum disorder (ASD) affects multiple body systems, including metabolic, mitochondrial, immunological, gastrointestinal, and neurological. Systems biology approaches can model these complex interactions for improved diagnosis and treatment.

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Area of Science:

  • Systems biology
  • Developmental disorders
  • Neuroscience

Background:

  • Autism spectrum disorder (ASD) is a rapidly growing developmental disorder with increasing prevalence.
  • ASD is characterized by social and communication impairments and repetitive movements, ranging from mild to profound.
  • The lifetime societal cost of care for individuals with ASD is substantial, necessitating better understanding and modeling.

Purpose of the Study:

  • To review research on how ASD impacts multiple body systems.
  • To explore the potential of a whole-body systems biology approach for modeling ASD.
  • To identify promising research areas for understanding ASD's complexity.

Main Methods:

  • Review of existing research on ASD's impact across various physiological systems.
  • Discussion of systems biology modeling techniques applicable to ASD.
  • Exploration of hierarchical, subgroup analysis, and longitudinal modeling approaches.

Main Results:

  • Evidence indicates ASD affects metabolic, mitochondrial, immunological, gastrointestinal, and neurological systems.
  • Common disturbances include oxidative stress, inflammation, and immune/mitochondrial dysfunction impacting multiple body cells.
  • These systems exhibit complex, interdependent interactions.

Conclusions:

  • A systems biology approach is crucial for modeling the multifaceted nature of ASD.
  • Understanding inter-system connections may lead to improved diagnosis, treatment, and quality of life for individuals with ASD.
  • Autism presents a valuable model system for advancing systems biology techniques.