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Sulfonates-PMMA nanoparticles conjugates: a versatile system for multimodal application.

Claudio Monasterolo1, Marco Ballestri, Giovanna Sotgiu

  • 1Istituto per la Sintesi Organica e la Fotoreattività, CNR-I.S.O.F., Area della Ricerca di Bologna, via P. Gobetti 101, Bologna, Italy.

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This summary is machine-generated.

Novel polymer nanoparticles show promise for theranostic applications, acting as effective carriers for drugs and bioimaging probes. These sulfonated poly(methylmethacrylate) nanoparticles demonstrate potential for targeted drug delivery and diagnostics.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Positively charged core-shell nanoparticles offer versatile platforms for drug and imaging agent delivery.
  • Developing efficient nanocarriers is crucial for advancing theranostic applications, combining diagnosis and therapy.

Purpose of the Study:

  • To investigate the viability of novel sulfonated organic salt-conjugated poly(methylmethacrylate) (PMMA)-based core-shell nanoparticles (NPs).
  • To evaluate the potential of these PMMA NPs@sulfonates systems for drug delivery and bioimaging applications.

Main Methods:

  • Synthesized PMMA core-shell NPs with a high density of ammonium groups.
  • Conjugated various sulfonated organic salts to the NPs via ionic and hydrophobic interactions.
  • Assessed in vitro cytotoxicity on NCI-H460 cells and in vivo efficacy against IGROV-1 cells.
  • Evaluated the internalization of 8-hydroxypyrene-1,3,6-trisulfonic acid, trisodium salt (HPTS) as a bioimaging probe in Hep G2 cells.

Main Results:

  • Demonstrated successful conjugation of sulfonates to PMMA NPs, creating sulfonates@EA0 systems.
  • Showcased the potential of these NPs as carriers for cytotoxic drugs and pro-drugs in cancer models.
  • Confirmed the ability of the NPs to carry and facilitate the internalization of fluorophores for bioimaging.
  • Validated the in vivo efficacy of the NPs as delivery systems for negatively charged drugs.

Conclusions:

  • The developed PMMA NPs@sulfonates systems are promising for theranostic applications.
  • These core-shell NPs exhibit potential as effective delivery systems for negatively charged drugs and biologically active molecules.
  • The high charge density allows for sequential loading, enabling bi-modal drug delivery or theranostic capabilities.